![]() Talk with your hematologist about whether you should get a flu shot. Seasonal flu vaccines protect against the three influenza viruses (trivalent) that research indicates will be most common during the upcoming season. Ask your doctor which ones are right for you. ![]() Patients with PNH should receive vaccinations against certain types of bacteria to prevent infection. This weakening may be caused by aplastic anemia or another mild and/or undiagnosed bone marrow failure disease. Some doctors believe this growth happens because people with PNH have bone marrow that is weaker than normal. In people with PNH, however, these stem cells grow fast and make lots of mature PNH red blood cells. Many healthy people have a small number of PNH stem cells. The PNH red blood cells lack the shield of proteins that protect normal red blood cells from the complement system, leaving them open to attack and destruction by the complement system proteins.The abnormal cells mature into red blood cells that have mutant PIG-A.This leads to a whole population of bone marrow stem cells that have mutant PIG-A. The abnormal stem cell makes copies of or "clones" itself.PNH occurs because of a genetic change ( mutation) in the PIG-A gene of a single stem cell in your bone marrow. PNH, along with aplastic anemia and MDS, are bone marrow failure diseases. This means the body can not supply itself with the blood it needs. Healthy people have enough stem cells to make all the blood cells they need.īone marrow failure happens when the marrow does not produce enough red cells, white cells or platelets, or the blood cells that are produced are damaged or defective. When blood cells are fully mature and functional, they leave the bone marrow and enter the bloodstream. Marrow contains blood-forming stem cells that make copies of themselves to create all 3 types of blood cells. Blood cells are made in the bone marrow, a spongy tissue located inside certain bones. The process of making blood cells is called hematopoiesis. They are small pieces of cells that help blood clot and stop bleeding. Platelets are also called thrombocytes. ![]() There are several kinds of white blood cells, each of which fights a different kind of germ. They fight disease and infection by attacking and killing germs that get into the body.
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